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Target
Mu-type opioid receptor
Ligand
BDBM50087825
Substrate
n/a
Meas. Tech.
ChEMBL_1478283 (CHEMBL3428523)
EC50
3000±n/a nM
Citation
 Burford, NT; Livingston, KE; Canals, M; Ryan, MR; Budenholzer, LM; Han, Y; Shang, Y; Herbst, JJ; O'Connell, J; Banks, M; Zhang, L; Filizola, M; Bassoni, DL; Wehrman, TS; Christopoulos, A; Traynor, JR; Gerritz, SW; Alt, A Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of thed-opioid receptor. J Med Chem 58:4220-9 (2015) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | hMOP | mu-type opioid receptor isoform MOR-1 | OPRM_HUMAN | OPRM1 | MOR1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Human
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50087825
Synonyms:
CHEMBL3426790
Type:
Small organic molecule
Emp. Form.:
C31H34O4
Mol. Mass.:
470.25
SMILES:
Cc1cccc(COc2ccc(cc2)C2C3=C(CC(C)(C)CC3=O)OC3=C2C(=O)CC(C)(C)C3)c1 |c:27,t:16|
Structure:
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