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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50089882
Substrate
n/a
Meas. Tech.
ChEMBL_1499283
IC50
313±n/a nM
Citation
 Blayo, AL; Maingot, M; Aicher, B; M'Kadmi, C; Schmidt, P; Müller, G; Teifel, M; Günther, E; Gagne, D; Denoyelle, S; Martinez, J; Fehrentz, JA New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists. Bioorg Med Chem Lett 25:20-4 (2014) [PubMed]  Article  BDB Entry
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50089882
Synonyms:
CHEMBL3581047
Type:
Small organic molecule
Emp. Form.:
C41H36N6O3
Mol. Mass.:
660.7629
SMILES:
COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1 |r|
Structure:
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