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Target
Prostaglandin E synthase
Ligand
BDBM50271083
Substrate
n/a
Meas. Tech.
ChEMBL_1495512 (CHEMBL3579896)
IC50
3940±n/a nM
Citation
 Luz, JG; Antonysamy, S; Kuklish, SL; Condon, B; Lee, MR; Allison, D; Yu, XP; Chandrasekhar, S; Backer, R; Zhang, A; Russell, M; Chang, SS; Harvey, A; Sloan, AV; Fisher, MJ Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. J Med Chem 58:4727-37 (2015) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
Prostaglandin E2 synthase-1 ( mPGES-1) | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | PTGES_HUMAN | PTGES | MGST1L1 | MPGES1 | PGES | PIG12 | Prostaglandin E synthase/G/H synthase 2
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Human
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50271083
Synonyms:
5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl)-2-((4-(trifluoromethyl)phenyl)ethynyl)pyridine | 5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl)-2-(2-(4-(trifluoromethyl)phenyl)ethynyl)pyridine | CHEMBL483894
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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