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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM50000102
Substrate
n/a
Meas. Tech.
ChEMBL_1454198 (CHEMBL3363498)
IC50
41200±n/a nM
Citation
 Kobayashi, T; Suemasa, A; Igawa, A; Ide, S; Fukuda, H; Abe, H; Arisawa, M; Minami, M; Shuto, S Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett 5:889-93 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GAT-3 | Solute carrier family 6 member 11 | S6A11_HUMAN | SLC6A11 | GABT3 | GAT3 | GABA transporter 3
Type:
PROTEIN
Mol. Mass.:
70607.60
Organism:
Human
Description:
ChEMBL_1454198
Residue:
632
Sequence:
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
  
Inhibitor
Name:
BDBM50000102
Synonyms:
omega-aminopropionic acid | Alanine-beta | beta-aminopropionic acid | beta-alanine | CHEMBL297569 | 3-aminopropanoic acidbeta-alanine
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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