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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50000102
Substrate
n/a
Meas. Tech.
ChEMBL_1454197 (CHEMBL3363497)
IC50
>100000±n/a nM
Citation
 Kobayashi, T; Suemasa, A; Igawa, A; Ide, S; Fukuda, H; Abe, H; Arisawa, M; Minami, M; Shuto, S Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett 5:889-93 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter 2 | GAT2 | S6A13_HUMAN | SLC6A13
Type:
PROTEIN
Mol. Mass.:
68012.63
Organism:
Human
Description:
ChEMBL_1454197
Residue:
602
Sequence:
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
  
Inhibitor
Name:
BDBM50000102
Synonyms:
3-aminopropanoic acidbeta-alanine | Alanine-beta | CHEMBL297569 | beta-alanine | beta-aminopropionic acid | omega-aminopropionic acid
Type:
Small organic molecule
Emp. Form.:
C3H7NO2
Mol. Mass.:
89.0932
SMILES:
NCCC(O)=O
Structure:
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