Target
Cysteinyl leukotriene receptor 2
Ligand
BDBM50104918
Substrate
n/a
Meas. Tech.
ChEMBL_1506283 (CHEMBL3599261)
IC50
3.6±n/a nM
Citation
 Itadani, SYashiro, KAratani, YSekiguchi, TKinoshita, AMoriguchi, HOhta, NTakahashi, SIshida, ATajima, YHisaichi, KIma, MUeda, JEgashira, HSekioka, TKadode, MYonetomi, YNakao, TInoue, ANomura, HKitamine, TFujita, MNabe, TYamaura, YMatsumura, NImagawa, ANakayama, YTakeuchi, JOhmoto, K Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem 58:6093-113 (2015) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Human
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50104918
Synonyms:
CHEMBL3597631
Type:
Small organic molecule
Emp. Form.:
C35H33F4NO5
Mol. Mass.:
623.6338
SMILES:
Cc1c(CCCC(O)=O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(O)=O
Structure:
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