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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50052024
Substrate
n/a
Meas. Tech.
ChEMBL_1506470 (CHEMBL3599869)
IC50
2.3±n/a nM
Citation
 Itadani, S; Yashiro, K; Aratani, Y; Sekiguchi, T; Kinoshita, A; Moriguchi, H; Ohta, N; Takahashi, S; Ishida, A; Tajima, Y; Hisaichi, K; Ima, M; Ueda, J; Egashira, H; Sekioka, T; Kadode, M; Yonetomi, Y; Nakao, T; Inoue, A; Nomura, H; Kitamine, T; Fujita, M; Nabe, T; Yamaura, Y; Matsumura, N; Imagawa, A; Nakayama, Y; Takeuchi, J; Ohmoto, K Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma. J Med Chem 58:6093-113 (2015) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Inhibitor
Name:
BDBM50052024
Synonyms:
CHEMBL787 | montelukast
Type:
Small organic molecule
Emp. Form.:
C35H36ClNO3S
Mol. Mass.:
586.183
SMILES:
CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |r|
Structure:
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