Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-beta
Ligand
BDBM50106289
Substrate
n/a
Meas. Tech.
ChEMBL_1506468 (CHEMBL3599867)
EC50
>10000±n/a nM
Citation
 Fauber, BP; Gobbi, A; Robarge, K; Zhou, A; Barnard, A; Cao, J; Deng, Y; Eidenschenk, C; Everett, C; Ganguli, A; Hawkins, J; Johnson, AR; La, H; Norman, M; Salmon, G; Summerhill, S; Ouyang, W; Tang, W; Wong, H Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett 25:2907-12 (2015) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | Retinoid-related orphan receptor-beta | RORB_HUMAN | RORB | NR1F2 | RZRB
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Human
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50106289
Synonyms:
CHEMBL3596270 | US9550771, Example 21
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: