Target
Transthyretin
Ligand
BDBM50109016
Substrate
n/a
Meas. Tech.
ChEMBL_1508575 (CHEMBL3602658)
Kd
1200±n/a nM
Citation
 Iakovleva, IBrännström, KNilsson, LGharibyan, ALBegum, AAnan, IWalfridsson, MSauer-Eriksson, AEOlofsson, A Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J Med Chem 58:6507-15 (2015) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50109016
Synonyms:
Aceclofenac | CHEBI:31159
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2NO4
Mol. Mass.:
354.185
SMILES:
OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: