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Target
Cholinesterase
Ligand
BDBM8961
Substrate
n/a
Meas. Tech.
ChEMBL_1510667 (CHEMBL3608118)
IC50
4.4±n/a nM
Citation
 Otto, R; Penzis, R; Gaube, F; Adolph, O; Föhr, KJ; Warncke, P; Robaa, D; Appenroth, D; Fleck, C; Enzensperger, C; Lehmann, J; Winckler, T Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders. J Med Chem 58:6710-5 (2015) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
Cholinesterase | CHLE_HORSE | BCHE | Butyrylcholinesterase (BuChE)
Type:
Enzyme
Mol. Mass.:
65643.35
Organism:
Horse
Description:
P81908
Residue:
574
Sequence:
EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNPNGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
  
Inhibitor
Name:
BDBM8961
Synonyms:
CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2,3,4-tetrahydroacridin-9-amine | Tracine | tacrine.HCl | 9-THA | 1,2,3,4-tetrahydro-9-acridinamine | 9-amino-1,2,3,4-tetrahydroacridine (THA) | Tacrine | US8999994, Tacrine
Type:
Small organic molecule
Emp. Form.:
C13H14N2
Mol. Mass.:
198.12
SMILES:
c1ccc2c(c1)c(c3c(n2)CCCC3)N
Structure:
Search PDB for entries with ligand similarity: