Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM50114871
Substrate
n/a
Meas. Tech.
ChEMBL_1512557 (CHEMBL3610506)
IC50
1200±n/a nM
Citation
 McConnell, JR; Buckton, LK; McAlpine, SR Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach. Bioorg Med Chem Lett 25:3409-14 (2015) [PubMed]  Article 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM50114871
Synonyms:
CHEMBL3609826
Type:
Small organic molecule
Emp. Form.:
C13H12N6O2
Mol. Mass.:
284.2734
SMILES:
CNc1ccc(c(Nc2ccc3[nH]ncc3c2)n1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: