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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50122849
Substrate
n/a
Meas. Tech.
ChEMBL_1520112 (CHEMBL3625576)
EC50
2.4±n/a nM
Citation
 Liu, P; Hu, Z; DuBois, BG; Moyes, CR; Hunter, DN; Zhu, C; Kar, NF; Zhu, Y; Garfunkle, J; Kang, L; Chicchi, G; Ehrhardt, A; Woods, A; Seo, T; Woods, M; van Heek, M; Dingley, KH; Pang, J; Salituro, GM; Powell, J; Terebetski, JL; Hornak, V; Campeau, LC; Lamberson, J; Ujjainwalla, F; Miller, M; Stamford, A; Wood, HB; Kowalski, T; Nargund, RP; Edmondson, SD Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes. ACS Med Chem Lett 6:936-41 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50122849
Synonyms:
CHEMBL3622173
Type:
Small organic molecule
Emp. Form.:
C21H25F2N3O3S
Mol. Mass.:
437.503
SMILES:
CS(=O)(=O)c1ccc(COC[C@@H]2C[C@@H]2C2CCN(CC2)c2ncc(F)cn2)cc1F |r|
Structure:
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