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Target
Kelch-like ECH-associated protein 1
Ligand
BDBM50130547
Substrate
n/a
Meas. Tech.
ChEMBL_1525531 (CHEMBL3637038)
IC50
>250000±n/a nM
Citation
 Jain, AD; Potteti, H; Richardson, BG; Kingsley, L; Luciano, JP; Ryuzoji, AF; Lee, H; Krunic, A; Mesecar, AD; Reddy, SP; Moore, TW Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem 103:252-68 (2015) [PubMed]  Article 
Target
Name:
Kelch-like ECH-associated protein 1
Synonyms:
Cytosolic inhibitor of Nrf2 | Kelch-like protein 19 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KEAP1 | INRF2 | KIAA0132 | KLHL19
Type:
PROTEIN
Mol. Mass.:
69664.53
Organism:
Human
Description:
ChEMBL_107924
Residue:
624
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
  
Inhibitor
Name:
BDBM50130547
Synonyms:
CHEMBL3632707
Type:
Small organic molecule
Emp. Form.:
C32H34N2O10S2
Mol. Mass.:
670.17
SMILES:
CCOC(=O)CN(c1ccc(N(CC(=O)OCC)S(=O)(=O)c2ccc(OC)cc2)c2ccccc12)S(=O)(=O)c1ccc(OC)cc1
Structure:
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