Reaction Details Report a problem with these data
Target
CviR transcriptional regulator
Ligand
BDBM50136221
Substrate
n/a
Meas. Tech.
ChEMBL_1547614 (CHEMBL3755484)
IC50
66080±n/a nM
Citation
 Bucio-Cano, A; Reyes-Arellano, A; Correa-Basurto, J; Bello, M; Torres-Jaramillo, J; Salgado-Zamora, H; Curiel-Quesada, E; Peralta-Cruz, J; Avila-Sorrosa, A Targeting quorum sensing by designing azoline derivatives to inhibit the N-hexanoyl homoserine lactone-receptor CviR: Synthesis as well as biological and theoretical evaluations. Bioorg Med Chem 23:7565-77 (2015) [PubMed]  Article 
Target
Name:
CviR transcriptional regulator
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
29723.76
Organism:
Chromobacterium violaceum
Description:
ChEMBL_765227
Residue:
265
Sequence:
MVISKPINARPLPAGLTASQQWTLLEWIHMAGHIETENELKAFLDQVLSQAPSERLLLALGRLNNQNQIQRLERVLNVSYPSDWLDQYMKENYAQHDPILRIHLGQGPVMWEERFNRAKGAEEKRFIAEATQNGMGSGITFSAASERNNIGSILSIAGREPGRNAALVAMLNCLTPHLHQAAIRVANLPPASPSNMPLSQREYDIFHWMSRGKTNWEIATILDISERTVKFHVANVIRKLNANNRTHAIVLGMHLAMPPSTVANE
  
Inhibitor
Name:
BDBM50136221
Synonyms:
CHEMBL3754734
Type:
Small organic molecule
Emp. Form.:
C17H17N3O2
Mol. Mass.:
295.3358
SMILES:
O=C(COc1ccc(cc1)C1=NCCN1)Nc1ccccc1 |t:11|
Structure:
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