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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_1548780 (CHEMBL3755181)
IC50
114800±n/a nM
Citation
 Ma, X; Lubin, H; Ioja, E; Kékesi, O; Simon, Á; Apáti, Á; Orbán, TI; Héja, L; Kardos, J; Markó, IE Straightforward and effective synthesis of¿-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes. Bioorg Med Chem Lett 26:417-23 (2016) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
Solute carrier family 6 member 11 | GAT-3 | Sodium- and chloride-dependent GABA transporter 4 | Sodium- and chloride-dependent GABA transporter 3 | S6A11_MOUSE | Slc6a11 | Gabt3 | Gabt4 | Gat-4 | Gat3 | Gat4 | GABA transporter
Type:
PROTEIN
Mol. Mass.:
69962.73
Organism:
Mouse
Description:
ChEMBL_1460090
Residue:
627
Sequence:
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF
  
Inhibitor
Name:
BDBM90787
Synonyms:
SMR000326834 | cid_11957555 | GUVACINE | MLS000859975 | Guvacine hydrochloride | 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.06
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
Search PDB for entries with ligand similarity: