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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_1548777 (CHEMBL3755178)
IC50
20900±n/a nM
Citation
 Ma, X; Lubin, H; Ioja, E; Kékesi, O; Simon, Á; Apáti, Á; Orbán, TI; Héja, L; Kardos, J; Markó, IE Straightforward and effective synthesis of¿-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes. Bioorg Med Chem Lett 26:417-23 (2016) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | Solute carrier family 6 member 1 | SC6A1_RAT | Slc6a1 | Gabt1 | Gat-1 | Gat1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Rat
Description:
ChEMBL_1472611
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM90787
Synonyms:
SMR000326834 | cid_11957555 | GUVACINE | MLS000859975 | Guvacine hydrochloride | 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.06
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
Search PDB for entries with ligand similarity: