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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50138047
Substrate
n/a
Meas. Tech.
ChEMBL_1549764 (CHEMBL3757320)
Ki
120±n/a nM
Citation
 Kinoshita, A; Higashino, M; Aratani, Y; Kakuuchi, A; Matsuya, H; Ohmoto, K Discovery of highly potent dual EP(2) and EP(3) agonists with subtype selectivity. Bioorg Med Chem Lett 26:1016-9 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
Prostanoid EP1 receptor | Prostaglandin E2 receptor EP1 subtype | PGE receptor, EP1 subtype | PE2R1_HUMAN | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype (EP1)
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Human
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50138047
Synonyms:
CHEMBL3753853
Type:
Small organic molecule
Emp. Form.:
C19H28N2O5S2
Mol. Mass.:
428.14
SMILES:
CCCCC(C)(C)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O |r|
Structure:
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