Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50140263
Substrate
n/a
Meas. Tech.
ChEMBL_1548137 (CHEMBL3754939)
IC50
1.9±n/a nM
Citation
 Blanco, MJVetman, TChandrasekhar, SFisher, MJHarvey, AChambers, MLin, CMudra, DOskins, JWang, XSYu, XPWarshawsky, AM Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile. Bioorg Med Chem Lett 26:931-5 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50140263
Synonyms:
CHEMBL3753286
Type:
Small organic molecule
Emp. Form.:
C23H19F3N2O4
Mol. Mass.:
444.4032
SMILES:
Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C(F)(F)F)-c1cccc(CO)c1
Structure:
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