Reaction Details
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Delta-type opioid receptor
Ligand
BDBM50041144
Substrate
n/a
Meas. Tech.
ChEMBL_1552640 (CHEMBL3762579)
Ki
3±n/a nM
Citation
Turnaturi, R; Aricò, G; Ronsisvalle, G; Parenti, C; Pasquinucci, L Multitarget opioid ligands in pain relief: New players in an old game. Eur J Med Chem 108:211-28 (2016) [PubMed] Article More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
Delta-type opioid receptor (DOR) | OPIATE Delta | Opioid receptor | DOR-1 | Delta-type opioid receptor | Opioid receptor A | Delta opioid receptor | Voltage-gated potassium channel | Opiate Delta 1 | Cytochrome P450 3A4 | OPRD_RAT | Oprd1 | Ror-a | Opioid receptors; mu & delta
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rat
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
Inhibitor
Name:
BDBM50041144
Synonyms:
(S)-2-Amino-N-((5S,8S)-5-benzyl-4,7,13,16-tetraoxo-hexadecahydro-3a,6,12,15-tetraaza-cyclopentacyclopentadecen-8-yl)-3-(4-hydroxy-phenyl)-propionamide | CHEMBL557035
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|
Structure:
