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Target
Alkaline phosphatase, placental type
Ligand
BDBM50241179
Substrate
n/a
Meas. Tech.
ChEMBL_1559915 (CHEMBL3776500)
pH
7.8±n/a
IC50
>400000±n/a nM
Comments
extracted
Citation
 Marquès, S; Buchet, R; Popowycz, F; Lemaire, M; Mebarek, S Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization. Bioorg Med Chem Lett 26:1457-9 (2016) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, placental type
Synonyms:
ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:
PROTEIN
Mol. Mass.:
57950.65
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1506090
Residue:
535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
  
Inhibitor
Name:
BDBM50241179
Synonyms:
(S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole (Levamisole) | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(Levamisole) | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(tetramisole) | CHEMBL1454 | LEVAMISOLE | LEVAMISOLE HYDROCHLORIDE | TCMDC-125847 | cid_68628 | levamisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole | tetramisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole
Type:
Small organic molecule
Emp. Form.:
C11H12N2S
Mol. Mass.:
204.291
SMILES:
C1CN2C[C@@H](N=C2S1)c1ccccc1 |r,c:5|
Structure:
Search PDB for entries with ligand similarity: