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Target
Solute carrier family 13 member 5
Ligand
BDBM50149244
Substrate
n/a
Meas. Tech.
ChEMBL_1557738 (CHEMBL3773097)
IC50
214±n/a nM
Citation
 Huard, K; Gosset, JR; Montgomery, JI; Gilbert, A; Hayward, MM; Magee, TV; Cabral, S; Uccello, DP; Bahnck, K; Brown, J; Purkal, J; Gorgoglione, M; Lanba, A; Futatsugi, K; Herr, M; Genung, NE; Aspnes, G; Polivkova, J; Garcia-Irizarry, CN; Li, Q; Canterbury, D; Niosi, M; Vera, NB; Li, Z; Khunte, B; Siderewicz, J; Rolph, T; Erion, DM Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family. J Med Chem 59:1165-75 (2016) [PubMed]  Article 
Target
Name:
Solute carrier family 13 member 5
Synonyms:
Na(+)/citrate cotransporter | Nact | S13A5_MOUSE | Slc13a5 | Sodium-coupled citrate transporter | Sodium-dependent citrate transporter | Solute carrier family 13 member 5
Type:
PROTEIN
Mol. Mass.:
63827.44
Organism:
Mus musculus
Description:
ChEMBL_116737
Residue:
572
Sequence:
MDSAKTCVTKFKSFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANTAVEASLGTLELLDKNKTSELPGSQVVFEDPNVQEQEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSKDVLNYASWFGFAFPNMVMMLVLAWLWLQCLYMRHNLKKTCICCGEKKRDTEKIAYKVLNEEYQKLGSLSYPECNVLFCFTLLVILWFSRDPGFMPGWLSFAWVEGNTVHITDATVAIFVAILLFIIPSQKPKFNFSSQTEEERKTPFYPPALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLAFMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTWGRAMFNLDNFPDWANSTSVNT
  
Inhibitor
Name:
BDBM50149244
Synonyms:
CHEMBL3771118
Type:
Small organic molecule
Emp. Form.:
C13H17NO6
Mol. Mass.:
283.2772
SMILES:
COc1ncc(C)cc1CC[C@@](O)(CC(O)=O)C(O)=O |r|
Structure:
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