Reaction Details Report a problem with these data
Target
Catechol O-methyltransferase
Ligand
BDBM50108877
Substrate
n/a
Meas. Tech.
ChEMBL_1558449 (CHEMBL3773325)
IC50
2.2±n/a nM
Citation
 Zhang, H; Tong, R; Bai, L; Shi, J; Ouyang, L Emerging targets and new small molecule therapies in Parkinson's disease treatment. Bioorg Med Chem 24:1419-30 (2016) [PubMed]  Article 
Target
Name:
Catechol O-methyltransferase
Synonyms:
Catechol O-methyltransferase | Catechol-O-methyltransferase | COMT_RAT | Comt
Type:
Enzyme
Mol. Mass.:
29594.09
Organism:
Rat
Description:
n/a
Residue:
264
Sequence:
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
  
Inhibitor
Name:
BDBM50108877
Synonyms:
CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone | Talcapone | (3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone | TOLCAPONE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: