Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM85050
Substrate
n/a
Meas. Tech.
ChEMBL_1568948 (CHEMBL3789067)
Ki
1.1±n/a nM
Citation
 Keller, M; Kuhn, KK; Einsiedel, J; Hübner, H; Biselli, S; Mollereau, C; Wifling, D; Svobodová, J; Bernhardt, G; Cabrele, C; Vanderheyden, PM; Gmeiner, P; Buschauer, A Mimicking of Arginine by Functionalized N(¿)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples. J Med Chem 59:1925-45 (2016) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 1
Synonyms:
neurotensin receptor type 1 | Neurotensin receptor 1 | NTR1_HUMAN | NTSR1 | NTRR | Dopamine receptor D2L/neurotensin receptor NTS1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Human
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM85050
Synonyms:
SR142948A | CAS_184162-64-9 | SR 142948A | SR142948 | US20240287046, Compound C-3
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)c1cc(ccc1n2c(cc(n2)C(=O)NC3(C4CC5CC(C4)CC3C5)C(=O)O)c6c(cccc6OC)OC)C(=O)N(C)CCCN(C)C
Structure:
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