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Target
Carbonic anhydrase 12
Ligand
BDBM50163863
Substrate
n/a
Meas. Tech.
ChEMBL_1572876 (CHEMBL3801012)
KON
380000 M-1s-1
Citation
 Talibov, VO; Linkuviene, V; Matulis, D; Danielson, UH Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII. J Med Chem 59:2083-93 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | Carbonate dehydratase XII | Tumor antigen HOM-RCC-3.1.3 | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII (CAXII) | Carbonic anhydrase XII (CA XII) | CAH12_HUMAN | CA12 | Carbonic anhydrase | Carbonic anhydrase XII
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Human
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50163863
Synonyms:
4-(1H-benzimidazol-1-ylacetyl)-2-chlorobenzenesulfonamide (2a) | carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 2 | CHEMBL3798446
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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