Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50163858
Substrate
n/a
Meas. Tech.
ChEMBL_1572899 (CHEMBL3801222)
pH
7.0000±n/a
KON
860000 M-1s-1
Comments
extracted
Citation
 Talibov, VO; Linkuviene, V; Matulis, D; Danielson, UH Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII. J Med Chem 59:2083-93 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | Carbonate dehydratase VII | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII) | CAH7_HUMAN | CA7 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Human
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50163858
Synonyms:
carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 7 | CHEMBL2443188
Type:
Small organic molecule
Emp. Form.:
C12H10ClN3O3S2
Mol. Mass.:
342.99
SMILES:
c1cnc(nc1)SCC(=O)c2ccc(c(c2)Cl)S(=O)(=O)N
Structure:
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