Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 2
Ligand
BDBM50172343
Substrate
n/a
Meas. Tech.
ChEMBL_1579541 (CHEMBL3810887)
IC50
>100000±n/a nM
Citation
 Chen, H; Yang, H; Wang, Z; Xie, X; Nan, F Discovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists. ACS Med Chem Lett 7:335-9 (2016) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50172343
Synonyms:
CHEMBL3809556
Type:
Small organic molecule
Emp. Form.:
C29H19Cl2N3O3
Mol. Mass.:
528.385
SMILES:
OC(=O)c1[nH]c2ccc(Cl)cc2c1\C=C\C(=O)Nc1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
Structure:
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