Target
Coagulation factor VII/Tissue factor
Ligand
BDBM50172786
Substrate
n/a
Meas. Tech.
ChEMBL_1578577 (CHEMBL3811618)
Ki
1.4±n/a nM
Citation
 Glunz, PWMueller, LCheney, DLLadziata, VZou, YWurtz, NRWei, AWong, PCWexler, RRPriestley, ES Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. J Med Chem 59:4007-18 (2016) [PubMed]  Article 
Target
Name:
Coagulation factor VII/Tissue factor
Synonyms:
Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 69535
Components:
This complex has 2 components.
Component 1
Name:
Tissue factor
Synonyms:
CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor
Type:
PROTEIN
Mol. Mass.:
33067.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_936735
Residue:
295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
  
Component 2
Name:
Coagulation factor VII
Synonyms:
Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator
Type:
Enzyme
Mol. Mass.:
51599.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
  
Inhibitor
Name:
BDBM50172786
Synonyms:
CHEMBL3809909
Type:
Small organic molecule
Emp. Form.:
C29H29N5O3
Mol. Mass.:
495.5723
SMILES:
CC1(C)COC(=O)Nc2cccc(CNC(=O)[C@H](Nc3ccc4c(N)nccc4c3)c3ccc1cc3)c2 |r|
Structure:
Search PDB for entries with ligand similarity: