Reaction Details
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Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM50184477
Substrate
n/a
Meas. Tech.
ChEMBL_1587102 (CHEMBL3825637)
IC50
790±n/a nM
Citation
Haile, PA; Votta, BJ; Marquis, RW; Bury, MJ; Mehlmann, JF; Singhaus, R; Charnley, AK; Lakdawala, AS; Convery, MA; Lipshutz, DB; Desai, BM; Swift, B; Capriotti, CA; Berger, SB; Mahajan, MK; Reilly, MA; Rivera, EJ; Sun, HH; Nagilla, R; Beal, AM; Finger, JN; Cook, MN; King, BW; Ouellette, MT; Totoritis, RD; Pierdomenico, M; Negroni, A; Stronati, L; Cucchiara, S; Ziólkowski, B; Vossenkämper, A; MacDonald, TT; Gough, PJ; Bertin, J; Casillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem 59:4867-80 (2016) [PubMed] Article More Info.:
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Inhibitor
Name:
BDBM50184477
Synonyms:
CHEMBL3822979
Type:
Small organic molecule
Emp. Form.:
C20H15F5N4O2
Mol. Mass.:
438.3507
SMILES:
CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2F)ccn1
Structure:
