Target
Mitogen-activated protein kinase 14
Ligand
BDBM50184765
Substrate
n/a
Meas. Tech.
ChEMBL_1587106 (CHEMBL3825641)
IC50
5119±n/a nM
Citation
 Haile, PAVotta, BJMarquis, RWBury, MJMehlmann, JFSinghaus, RCharnley, AKLakdawala, ASConvery, MALipshutz, DBDesai, BMSwift, BCapriotti, CABerger, SBMahajan, MKReilly, MARivera, EJSun, HHNagilla, RBeal, AMFinger, JNCook, MNKing, BWOuellette, MTTotoritis, RDPierdomenico, MNegroni, AStronati, LCucchiara, SZiólkowski, BVossenkämper, AMacDonald, TTGough, PJBertin, JCasillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem 59:4867-80 (2016) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50184765
Synonyms:
CHEMBL3823499
Type:
Small organic molecule
Emp. Form.:
C20H19FN4O2S
Mol. Mass.:
398.454
SMILES:
CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1
Structure:
Search PDB for entries with ligand similarity: