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Target
WD repeat-containing protein 5
Ligand
BDBM50164794
Substrate
n/a
Meas. Tech.
ChEMBL_1587989 (CHEMBL3824743)
Kd
93±n/a nM
Citation
 Li, DD; Chen, WL; Xu, XL; Jiang, F; Wang, L; Xie, YY; Zhang, XJ; Guo, XK; You, QD; Sun, HP Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5. Eur J Med Chem 118:1-8 (2016) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50164794
Synonyms:
CHEMBL3798846 | US11174250, Example Table4.1.1 | US11319299, Comp. No. 57
Type:
Small organic molecule
Emp. Form.:
C29H32F3N5O3
Mol. Mass.:
555.5913
SMILES:
CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1
Structure:
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