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Target
Renin
Ligand
BDBM50195788
Substrate
n/a
Meas. Tech.
ChEMBL_1617919 (CHEMBL3859988)
IC50
0.580000±n/a nM
Citation
 Imaeda, Y; Tokuhara, H; Fukase, Y; Kanagawa, R; Kajimoto, Y; Kusumoto, K; Kondo, M; Snell, G; Behnke, CA; Kuroita, T Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor. ACS Med Chem Lett 7:933-938 (2016) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50195788
Synonyms:
CHEMBL3961799
Type:
Small organic molecule
Emp. Form.:
C23H35N5O2
Mol. Mass.:
413.5563
SMILES:
CC(C)CN([C@H]1CCCNC1)C(=O)c1cnc(nc1NCc1ccco1)C(C)(C)C |r|
Structure:
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