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Target
Carbonic anhydrase 12
Ligand
BDBM50262062
Substrate
n/a
Meas. Tech.
ChEMBL_1619739 (CHEMBL3861908)
Ki
6.0±n/a nM
Citation
 Nocentini, A; Ferraroni, M; Carta, F; Ceruso, M; Gratteri, P; Lanzi, C; Masini, E; Supuran, CT Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations. J Med Chem 59:10692-10704 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50262062
Synonyms:
4-(4-phenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide | CHEMBL513184
Type:
Small organic molecule
Emp. Form.:
C14H12N4O2S
Mol. Mass.:
300.336
SMILES:
NS(=O)(=O)c1ccc(cc1)-n1cc(nn1)-c1ccccc1
Structure:
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