Target
17-beta-hydroxysteroid dehydrogenase 14
Ligand
BDBM50197841
Substrate
n/a
Meas. Tech.
ChEMBL_1619749 (CHEMBL3861918)
Ki
9.0±n/a nM
Citation
 Braun, FBertoletti, NMöller, GAdamski, JSteinmetzer, TSalah, MAbdelsamie, ASvan Koppen, CJHeine, AKlebe, GMarchais-Oberwinkler, S First Structure-Activity Relationship of 17ß-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J Med Chem 59:10719-10737 (2016) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase 14
Synonyms:
17-beta-HSD 14 | 17-beta-hydroxysteroid dehydrogenase 14 | 17-beta-hydroxysteroid dehydrogenase DHRS10 | DHB14_HUMAN | DHRS10 | DHRS10 | Dehydrogenase/reductase SDR family member 10 | HSD17B14 | Retinal short-chain dehydrogenase/reductase retSDR3 | SDR3 | SDR47C1 | Short chain dehydrogenase/reductase family 47C member 1
Type:
PROTEIN
Mol. Mass.:
28316.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_114829
Residue:
270
Sequence:
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS
  
Inhibitor
Name:
BDBM50197841
Synonyms:
CHEMBL3932068
Type:
Small organic molecule
Emp. Form.:
C26H20FNO4
Mol. Mass.:
429.4397
SMILES:
Cc1cc(ccc1O)-c1ccc(nc1-c1ccc(O)c(C)c1)C(=O)c1ccc(F)c(O)c1
Structure:
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