Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50301375
Substrate
n/a
Meas. Tech.
ChEMBL_1620067 (CHEMBL3862350)
IC50
2200±n/a nM
Citation
 Simões, CJV; Almeida, ZL; Costa, D; Jesus, CSH; Cardoso, AL; Almeida, MR; Saraiva, MJ; Pinho E Melo, TMVD; Brito, RMM A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition. Eur J Med Chem 121:823-840 (2016) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50301375
Synonyms:
3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetraiodo-L-thyronine | 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine | CHEMBL1624 | L-T4 | L-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine | levothyroxine
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |r|
Structure:
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