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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50198641
Substrate
n/a
Meas. Tech.
ChEMBL_1620800
EC50
148±n/a nM
Citation
 Rak, A; Canale, V; Marciniec, K; Zmudzki, P; Kotanska, M; Knutelska, J; Siwek, A; Stachowicz, G; Bednarski, M; Nowinski, L; Zygmunt, M; Zajdel, P; Sapa, J Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines asa Bioorg Med Chem 24:5582-5591 (2016) [PubMed]  Article  BDB Entry
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50198641
Synonyms:
CHEMBL3937911
Type:
Small organic molecule
Emp. Form.:
C21H26ClFN2O4S
Mol. Mass.:
456.959
SMILES:
COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cc(Cl)ccc2F)CC1
Structure:
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