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Target
Metabotropic glutamate receptor 3
Ligand
BDBM50204256
Substrate
n/a
Meas. Tech.
ChEMBL_1627029 (CHEMBL3869550)
IC50
30±n/a nM
Citation
 Dressman, BA; Tromiczak, EG; Chappell, MD; Tripp, AE; Quimby, SJ; Vetman, T; Fivush, AM; Matt, J; Jaramillo, C; Li, R; Khilevich, A; Blanco, MJ; Smith, SC; Carpintero, M; de Diego, JE; Barberis, M; García-Cerrada, S; Soriano, JF; Schkeryantz, JM; Witkin, JM; Wafford, KA; Seidel, W; Britton, T; Overshiner, CD; Li, X; Wang, XS; Heinz, BA; Catlow, JT; Swanson, S; Bedwell, D; Ornstein, PL; Mitch, CH Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression. Bioorg Med Chem Lett 26:5663-5668 (2016) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 3
Synonyms:
metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c | GRM3_HUMAN | GRM3 | GPRC1C | MGLUR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
98889.09
Organism:
Human
Description:
metabotropic glutamate 1c 0 HUMAN::Q14832
Residue:
879
Sequence:
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50204256
Synonyms:
CHEMBL3948272
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: