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Target
Peroxiredoxin-like 2A
Ligand
BDBM50357312
Substrate
n/a
Meas. Tech.
ChEMBL_1634422 (CHEMBL3877214)
IC50
900±n/a nM
Citation
 Munoz, L Non-kinase targets of protein kinase inhibitors. Nat Rev Drug Discov 16:424-440 (2017) [PubMed]  Article 
Target
Name:
Peroxiredoxin-like 2A
Synonyms:
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes | Protein PAMM | Redox-regulatory protein FAM213A | PXL2A_HUMAN | PRXL2A | C10orf58 | FAM213A | PAMM
Type:
PROTEIN
Mol. Mass.:
25768.88
Organism:
Human
Description:
ChEMBL_116949
Residue:
229
Sequence:
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK
  
Inhibitor
Name:
BDBM50357312
Synonyms:
IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US9278100, 1 | US10124003, Ref. Ex. Compound 1 | PCI-32765 | US10711006, Compound Ibrutinib | US10919899, Ibrutinib | US10835536, Ref. Ex. Comp 1 | US10793575, Example ibrutinib | US11186578, Example Ibrutinib | US11078206, Example Ibrutinib | US11407754, Example Ibrutinib | US11339167, Example Ibrutinib | US20230364079, Example Ibrutinib | US20240059694, Compound Ibrutinib | US20240139326, Compound Ibrutinib | US20240358707, Compound 13 | US20250304585, Compound Ibrutinib
Type:
Small organic molecule
Emp. Form.:
C25H24N6O2
Mol. Mass.:
n/a
SMILES:
Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Structure:
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