Target
Ferrochelatase, mitochondrial
Ligand
BDBM50396483
Substrate
n/a
Meas. Tech.
ChEMBL_1634427 (CHEMBL3877219)
EC50
5012±n/a nM
Citation
 Munoz, L Non-kinase targets of protein kinase inhibitors. Nat Rev Drug Discov 16:424-440 (2017) [PubMed]  Article 
Target
Name:
Ferrochelatase, mitochondrial
Synonyms:
4.99.1.1 | FECH | Ferrochelatase, mitochondrial | HEMH_HUMAN | Heme synthase | Protoheme ferro-lyase
Type:
PROTEIN
Mol. Mass.:
47876.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116956
Residue:
423
Sequence:
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
  
Inhibitor
Name:
BDBM50396483
Synonyms:
PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB
Type:
Small organic molecule
Emp. Form.:
C23H18ClF2N3O3S
Mol. Mass.:
489.922
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Structure:
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