Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50159089
Substrate
n/a
Meas. Tech.
ChEMBL_1635860 (CHEMBL3878758)
Ki
2.7±n/a nM
Citation
 Kim, T; Yang, HY; Park, BG; Jung, SY; Park, JH; Park, KD; Min, SJ; Tae, J; Yang, H; Cho, S; Cho, SJ; Song, H; Mook-Jung, I; Lee, J; Pae, AN Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease. Eur J Med Chem 125:1172-1192 (2017) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50159089
Synonyms:
CHEMBL180523 | N,N-Dibutyl-2-[6,8-dichloro-2-(4-chloro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C23H26Cl3N3O
Mol. Mass.:
466.831
SMILES:
CCCCN(CCCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: