Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50210940
Substrate
n/a
Meas. Tech.
ChEMBL_1635890 (CHEMBL3878788)
Ki
23±n/a nM
Citation
 Kim, T; Yang, HY; Park, BG; Jung, SY; Park, JH; Park, KD; Min, SJ; Tae, J; Yang, H; Cho, S; Cho, SJ; Song, H; Mook-Jung, I; Lee, J; Pae, AN Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease. Eur J Med Chem 125:1172-1192 (2017) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50210940
Synonyms:
CHEMBL3948914
Type:
Small organic molecule
Emp. Form.:
C26H25Cl2N3O
Mol. Mass.:
466.402
SMILES:
CC(C)c1ccc(C)c(NC(=O)Cn2c(Cc3c(Cl)cccc3Cl)nc3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: