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Target
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
Ligand
BDBM50215106
Substrate
n/a
Meas. Tech.
ChEMBL_17044 (CHEMBL630618)
EC50
20000±n/a nM
Citation
  TBA Bioorg Med Chem Lett 7:945-948 (1997)   
Target
Name:
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
Synonyms:
cAMP-dependent protein kinase (PKA)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 217489
Components:
This complex has 3 components.
Component 1
Name:
cAMP-dependent protein kinase catalytic subunit beta
Synonyms:
PKA C-beta | cAMP-dependent protein kinase catalytic subunit beta | cAMP-dependent protein kinase beta-1 catalytic subunit | PKAC-beta | KAPCB_HUMAN | PRKACB | cAMP-dependent protein kinase (PKA)
Type:
PROTEIN
Mol. Mass.:
40631.25
Organism:
Human
Description:
ChEMBL_586348
Residue:
351
Sequence:
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
  
Component 2
Name:
cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:
cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase, alpha-catalytic subunit | PKA C-alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | KAPCA_HUMAN | PRKACA | PKACA | cAMP-dependent protein kinase (PKA)
Type:
Enzyme Catalytic Subunit
Mol. Mass.:
40598.73
Organism:
Human
Description:
n/a
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
  
Component 3
Name:
cAMP-dependent protein kinase catalytic subunit gamma
Synonyms:
PKA C-gamma | cAMP-dependent protein kinase catalytic subunit gamma | cAMP-dependent protein kinase (PKA) | KAPCG_HUMAN | PRKACG
Type:
PROTEIN
Mol. Mass.:
40442.03
Organism:
Human
Description:
ChEMBL_104720
Residue:
351
Sequence:
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
  
Inhibitor
Name:
BDBM50215106
Synonyms:
CHEMBL230552 | CHEBI:84612 | 8-pCPT-cAMP
Type:
Small organic molecule
Emp. Form.:
C16H15ClN5O6PS
Mol. Mass.:
471.02
SMILES:
[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1c(Sc2ccc(Cl)cc2)nc2c(N)ncnc12 |r|
Structure:
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