Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1/2
Ligand
BDBM50009073
Substrate
n/a
Meas. Tech.
ChEMBL_98640 (CHEMBL708865)
Ki
2±n/a nM
Citation
 Chambers, RJ; Antognoli, GW; Cheng, JB; Marfat, A; Pillar, JS; Shirley, JT; Watson, JW Development of new chromanol antagonists of leukotriene D4. Bioorg Med Chem Lett 8:1791-6 (1998) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1/2
Synonyms:
Cysteinyl leukotriene receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 98640
Components:
This complex has 2 components.
Component 1
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
Leukotriene Cysteinyl 1 | Cysteinyl leukotriene receptor | HMTMF81 | LTD4 receptor | Cysteinyl leukotriene D4 receptor | HG55 | CLTR1_HUMAN | CYSLTR1 | CYSLT1 | Cysteinyl leukotriene receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Human
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Component 2
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
Leukotriene Cysteinyl 2 | Cysteinyl leukotriene receptor 2 | CLTR2_HUMAN | CYSLTR2 | CYSLT2 | CYSLT2R | Cysteinyl leukotriene receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Human
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50009073
Synonyms:
cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate | CHEMBL603 | 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide | cyclopentyl 3-[2-methoxy-4-(2-methylphenylsulfonylcarbamoyl)benzyl]-1-methyl-1H-indol-5-ylcarbamate | ZAFIRLUKAST
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: