Reaction Details
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cAMP-dependent protein kinase catalytic subunit gamma
Ligand
BDBM50228843
Substrate
n/a
Meas. Tech.
ChEMBL_161403 (CHEMBL768312)
IC50
3.0±n/a nM
Citation
Ricouart, A; Gesquiere, JC; Tartar, A; Sergheraert, C Design of potent protein kinase inhibitors using the bisubstrate approach. J Med Chem 34:73-8 (1991) [PubMed] Article More Info.:
Target
Name:
cAMP-dependent protein kinase catalytic subunit gamma
Synonyms:
PKA C-gamma | cAMP-dependent protein kinase catalytic subunit gamma | cAMP-dependent protein kinase (PKA) | KAPCG_HUMAN | PRKACG
Type:
PROTEIN
Mol. Mass.:
40442.03
Organism:
Human
Description:
ChEMBL_104720
Residue:
351
Sequence:
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
Inhibitor
Name:
BDBM50228843
Synonyms:
CHEMBL436718
Type:
Small organic molecule
Emp. Form.:
C53H94N28O12S
Mol. Mass.:
1346.73
SMILES:
NC(=N)NCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)CCNCCNS(=O)(=O)c1cccc2cnccc12)C(O)=O
Structure:
