Target
Heat shock factor protein 1
Ligand
BDBM50234087
Substrate
n/a
Meas. Tech.
ChEMBL_1652055 (CHEMBL4001310)
IC50
<10000±n/a nM
Citation
 Cheeseman, MDChessum, NERye, CSPasqua, AETucker, MJWilding, BEvans, LELepri, SRichards, MSharp, SYAli, SRowlands, MO'Fee, LMiah, AHayes, AHenley, ATPowers, MTe Poele, RDe Billy, EPellegrino, LRaynaud, FBurke, Rvan Montfort, RLEccles, SAWorkman, PJones, K Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J Med Chem 60:180-201 (2017) [PubMed]  Article 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM50234087
Synonyms:
CHEMBL4091297
Type:
Small organic molecule
Emp. Form.:
C28H25N3O4
Mol. Mass.:
467.5158
SMILES:
Cc1ccc2cc(ccc2n1)C(=O)Nc1c(C)ccc(NC(=O)c2ccc3OCCOc3c2)c1C
Structure:
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