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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM24566
Substrate
n/a
Meas. Tech.
ChEMBL_1658549 (CHEMBL4008161)
KOFF
0.360000 s-1
Citation
 Piemontese, L; Cerchia, C; Laghezza, A; Ziccardi, P; Sblano, S; Tortorella, P; Iacobazzi, V; Infantino, V; Convertini, P; Dal Piaz, F; Lupo, A; Colantuoni, V; Lavecchia, A; Loiodice, F New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. Eur J Med Chem 127:379-397 (2017) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Peroxisome proliferator-activated receptor | PPAR-alpha | Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor alpha (PPAR alpha) | PPARA_HUMAN | PPARA | NR1C1 | PPAR
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Human
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM24566
Synonyms:
JMC515449 Compound 1 | Wyeth 14,643 | 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid | CHEMBL295416 | Pirinixic acid
Type:
Small organic molecule
Emp. Form.:
C14H14ClN3O2S
Mol. Mass.:
323.05
SMILES:
Cc1cccc(c1C)Nc2cc(nc(n2)SCC(=O)O)Cl
Structure:
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