Reaction Details Report a problem with these data
Target
Nucleotide triphosphate diphosphatase NUDT15
Ligand
BDBM50236118
Substrate
n/a
Meas. Tech.
ChEBML_1658778
IC50
>100000±n/a nM
Citation
 Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem 60:2148-2154 (2017) [PubMed]  Article 
Target
Name:
Nucleotide triphosphate diphosphatase NUDT15
Synonyms:
3.6.1.9 | MutT homolog 2 | Nucleoside diphosphate-linked moiety X motif 15 | Nucleoside diphosphate-linked to another moiety X hydrolase 15 | Nucleotide triphosphate diphosphatase NUDT15 | Nudix hydrolase 15 | Nudix motif 15 | Synonyms=MTH2 | NUD15_HUMAN | NUDT15 | MTH2
Type:
PROTEIN
Mol. Mass.:
18606.77
Organism:
Human
Description:
ChEMBL_117432
Residue:
164
Sequence:
MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL
  
Inhibitor
Name:
BDBM50236118
Synonyms:
CHEMBL4065181
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2S2
Mol. Mass.:
344.04
SMILES:
COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure:
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