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Target
Dihydrofolate reductase
Ligand
BDBM50237208
Substrate
n/a
Meas. Tech.
ChEMBL_1660724 (CHEMBL4010336)
IC50
25000±n/a nM
Citation
 Gopalsamy, A; Narayanan, A; Liu, S; Parikh, MD; Kyne, RE; Fadeyi, O; Tones, MA; Cherry, JJ; Nabhan, JF; LaRosa, G; Petersen, DN; Menard, C; Foley, TL; Noell, S; Ren, Y; Loria, PM; Maglich-Goodwin, J; Rong, H; Jones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem 60:3094-3108 (2017) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase | DYR_HUMAN | DHFR
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Human
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50237208
Synonyms:
CHEMBL4090641
Type:
Small organic molecule
Emp. Form.:
C12H16N4O2
Mol. Mass.:
248.13
SMILES:
COC[C@@H](C)Oc1cccc2nc(N)nc(N)c12 |r|
Structure:
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