Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM35229
Substrate
n/a
Ki
31±n/a nM
Comments
PDSP_638
Citation
Owens, MJ; Morgan, WN; Plott, SJ; Nemeroff, CB Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 283:1305-22 (1997) [PubMed]
More Info.:
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
Inhibitor
Name:
BDBM35229
Synonyms:
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine | 5-(gamma-methylaminopropyl)iminodibenzyl | CHEMBL72 | DESIPRAMINE HYDROCHLORIDE | DMI | Desipramin | Desipramine | Desmethylimipramine | N-(3-methylaminopropyl)iminobibenzyl | US9944618, Compound ID No. 174 | demethylimipramine | monodemethylimipramine | norimipramine
Type:
Small organic molecule
Emp. Form.:
C18H22N2
Mol. Mass.:
266.3807
SMILES:
CNCCCN1c2ccccc2CCc2ccccc12