Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM7882
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_970
Citation
 Lovenberg, TW; Roland, BL; Wilson, SJ; Jiang, X; Pyati, J; Huvar, A; Jackson, MR; Erlander, MG Cloning and functional expression of the human histamine H3 receptor. Mol Pharmacol 55:1101-7 (1999) [PubMed] 
Target
Name:
Histamine H3 receptor
Synonyms:
HRH3_HUMAN | HRH3 | GPCR97 | G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Human
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM7882
Synonyms:
CHEMBL540 | 1H-imidazole | imidazole | Imidazole (Im) | US9138393, Imidazole | US9144538, Imidazole
Type:
Small organic molecule
Emp. Form.:
C3H4N2
Mol. Mass.:
68.04
SMILES:
c1c[nH]cn1
Structure:
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