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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM22418
Substrate
n/a
Ki
197±n/a nM
Comments
PDSP_556
Citation
 Paczkowski, FA; Bryan-Lluka, LJ; Pörzgen, P; Brüss, M; Bönisch, H Comparison of the pharmacological properties of cloned rat, human, and bovine norepinephrine transporters. J Pharmacol Exp Ther 290:761-7 (1999) [PubMed] 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
NORADR | Norepinephrine transporter | SC6A2_BOVIN | SLC6A2 | Sodium-dependent noradrenaline transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
68909.35
Organism:
BOVINE
Description:
Norepinephrine transporter 0 BOVINE::P51143
Residue:
615
Sequence:
MLLARMNPQVQPENGGAGPGSEQPPRKRKEVLVVKERNGVQCLLASRDGDEQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTPTLPWTDCGHAWNSPNCTDPKLLNSSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLIIVVIVLFFSLWKGVKTSGKVVWITATLPYLVLFVLLVHGITLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAIVFFIMLLALGIDSSMGGMEAVITGLADDFQVLKRHRKLFTFAVSFGTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVIVSIINFKPLTYDDYIFPLWANWVGWGIAGSSMVLVPAYIVYKFFSTRGSIRERLAYGITPASEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM22418
Synonyms:
Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | methyl (1R,2R,3S,5S)-8-methyl-3-[(phenylcarbonyl)oxy]-8-azabicyclo[3.2.1]octane-2-carboxylate
Type:
n/a
Emp. Form.:
C17H21NO4
Mol. Mass.:
303.3529
SMILES:
[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2|
Structure:
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